[PDF] Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns | Semantic Scholar (2024)

611 Citations

Maternal Vascular Underperfusion: Nosology and Reproducibility of Placental Reaction Patterns
    R. RedlineT. Boyd Perinatal Section Maternal Vascular Underperfusion Nosology for the Society for Pediatric Pathology


    Pediatric and developmental pathology : the…

  • 2004

Correlation of maternal vessel and implantation site lesions with the clinical diagnosis of preeclampsia showed that excessive placental site giant cells and immature intermediate trophoblast were more sensitive and efficient predictors, whereas atherosis and muscularized basal plate arteries were more specific.

  • 340
Fetal Vascular Obstructive Lesions: Nosology and Reproducibility of Placental Reaction Patterns
    R. RedlineI. Ariel Perinatal Section Amniotic Fluid Infection Nosology Committe the Society for Pediatric Pathology


    Pediatric and developmental pathology : the…

  • 2004

It is proposed that this combined group of villous lesions be dichotomized with the terms fetal thrombotic vasculopathy or extensive avascular villi (and/or villous stromal-vascular karyorrhexis) being reserved for the group with 15 or more affected terminal villi per section.

  • 283
Pathologist interobserver variability in diagnosing acute ascending intrauterine infection.
    Khaldoon Aljerian


    Annals of diagnostic pathology

  • 2021
  • 1
Accuracy of signs of clinical chorioamnionitis in the term parturient
    William M. CurtinWilliam M. CurtinPhilip J. KatzmanH. FlorescueL. Metlay


    Journal of Perinatology

  • 2013

Histologic chorioamnionitis, frequently asymptomatic, is a common finding in placentas examined from term parturients and adoption of uniform pathologic guidelines will facilitate research into the clinical significance of these lesions in the future.

  • 55
Classification of placental lesions.
    R. Redline


    American journal of obstetrics and gynecology

  • 2015
  • 324
  • PDF
Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement.

The group agreed on sets of uniform sampling criteria, placental gross descriptors, pathologic terminologies, and diagnostic criteria for placental lesions, which will assist in international comparability of clinicopathologic and scientific studies and assist in refining the significance of lesions associated with adverse pregnancy and later health outcomes.

  • 1,037
  • PDF
Placental diagnostic criteria and clinical correlation--a workshop report.
    R. RedlineD. HellerS. KeatingJ. Kingdom



  • 2005
  • 277
Interobserver Reliability for Identifying Specific Patterns of Placental Injury as Defined by the Amsterdam Classification.
    R. RedlineT. Vik M. Oskoui


  • 2021

Although reliability was good to excellent for inflammatory lesions, lower reliability for vascular lesions emphasizes the need to more explicitly define the specific histologic features and boundaries for these patterns.

  • 14
  • PDF
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis.
    Claudia Patricia Cataño SabogalJavier E FonsecaH. García-Perdomo


    European journal of obstetrics, gynecology, and…

  • 2018
  • 31
Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis
    Khaldoon Aljerian


  • 2020

Clinical diagnosis for chorioamnionitis is inaccurate; in this study, most of the positive cases were not diagnosed using clinical indicators, however, of the clinical indicators examined, maternal and fetal tachycardia were the most reliable.

  • 9
  • PDF



53 References

Discrepancy in pathologic diagnosis of placental lesions.
    Chen-Chih J. SunVania O RevellAnthony J BelliR. Viscardi


  • 2002

It is common for general surgical pathologists not to recognize placental lesions, which may have clinical significance, and awareness of this deficiency, standardization of diagnostic criteria, and increased knowledge in placental pathology may improve the quality of diagnosis in this area.

  • 74
Methods to improve the reliability of histopathological diagnoses in the placenta.
    L. BeebeL. CowanS. HydeG. Altshuler


    Paediatric and perinatal epidemiology

  • 2000

This study demonstrated reliable placental diagnoses can be achieved through a standardised protocol through a developed and pilot-tested protocol for diagnosis and grading of features.

  • 35
Chronic deciduitis in the placental basal plate: definition and interobserver reliability.
    T. KhongR. Bendon A. Staples


    Human pathology

  • 2000
  • 100
Chorioamnionitis: a comparative histologic, bacteriologic, and clinical study.
    Jianmin ZhangFrederick T. KrausTomas I. Aquino


    International journal of gynecological pathology…

  • 1985

Using morphologic and bacteriologic techniques, placentas from 224 deliveries considered potentially complicated by infection were examined, finding higher grades of histologically demonstrable chorioamnionitis are associated significantly with the highest rates of neonatal morbidity or mortality.

  • 50
Chronic Chorioamnionitis: A Clinicopathologic Study of 17 Cases
    D. GersellN. PhillipsK. Beckerman


    International journal of gynecological pathology…

  • 1991

Summary:The clinicopathologic features of 17 cases of an unusual variant of Chorioamnionitis distinguished by a pure or predominantly chronic inflammatory infiltrate in the fetal membranes rather

  • 63
Clinical and pathologic aspects of recurrent placental villitis.
    R. RedlineC. Abramowsky


    Human pathology

  • 1985
  • 139
Placental pathology compared with clinical outcome: a retrospective blind review.
    W. KeenanJ. SteichenK. MahmoodG. Altshuler


    American journal of diseases of children

  • 1977

Triple vessel vasculitis in the umbilical cord vessels and chorionic microabscesses were significantly related to the incidence of proven, probable, and possible clinical sepsis.

  • 21
Reliability of placental histology using archived specimens.
    J. GretherA. EatonR. RedlineR. BendonK. BenirschkeK. Nelson


    Paediatric and perinatal epidemiology

  • 1999

Inter-rater reliability in the assessment of placental histological features possibly associated with neonatal illness and long-term neurological outcome was evaluated using archived specimens.

  • 39
Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis.
    M. OhyamaY. Itani Yukichi Tanaka


    Human pathology

  • 2002

It is proved that prolonged inflammation of the chorionic plate is a distinctive entity and should be differentiated from acute chorioamnionitis (ACAM), which is an excellent prognostic indicator of chronic lung disease (CLD), including Wilson-Mikity syndrome (WMS).

  • 53
The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology.
    R. RomeroC. Salafia M. Bracken


    American journal of obstetrics and gynecology

  • 1992
  • 234



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Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns
 | Semantic Scholar (2024)


    What is the amniotic infection syndrome? ›

    The amniotic infection "syndrome" comprises the inflammatory lesions displayed by the placenta, cord and membranes and by the fetal organs (essentially by the lungs) which may be contaminated before and after birth.

    What does chorioamnionitis smell like? ›

    If you can't tell if you're leaking amniotic fluid, take the sniff test: Urine smells like ammonia; amniotic fluid has a sweeter smell, or if it's infected, it'll have a more foul smell.

    What is the only reliable indicator for the diagnosis of chorioamnionitis? ›

    The key clinical findings associated with clinical chorioamnionitis include fever, uterine fundal tenderness, maternal tachycardia (>100/min), fetal tachycardia (>160/min) and purulent or foul amniotic fluid [2,4]. Maternal fever is the most important clinical sign of chorioamnionitis.

    What are the long-term effects of chorioamnionitis on the baby? ›

    Multiple epidemiological studies have linked perinatal brain injury such as cerebral palsy, periventricular leukomalacia, and IVH with chorioamnionitis. Chorioamnionitis is associated with an increased incidence of speech delay and hearing loss at 18 months of corrected age in infants born very preterm.

    How do you treat an amniotic infection? ›


    Diagnosis is by specific clinical criteria or, for subclinical infection, analysis of amniotic fluid. Treatment includes broad-spectrum antibiotics, antipyretics, and delivery.

    Can you sue for chorioamnionitis? ›

    Getting Help for Your Chorioamnionitis Claim

    If you believe your child has suffered a birth injury that could have been prevented if the doctor had met that standard of care, you may have a medical malpractice lawsuit. You and your child may be entitled to receive financial compensation.

    How do you know if your placenta is infected? ›

    Chorioamnionitis is an infection of the placenta and the amniotic fluid. It happens more often when the amniotic sac is broken for a long time before birth. The major symptom is fever. Other symptoms include a fast heart rate, sore or painful uterus, and amniotic fluid that smells bad.

    Do babies survive chorioamnionitis? ›

    Infections during labor and delivery are usually caught early enough to prevent serious health problems. With proper care, most babies will fully recover from this infection. If not, then they could develop sepsis, severe respiratory problems, pneumonia, meningitis or brain damage.

    What does chorioamnionitis pain feel like? ›

    If you do have symptoms of chorioamnionitis, they can include: high temperature. pain in your abdomen and tenderness over the womb (in your pelvic area) your heart suddenly beating much faster (tachycardia)

    What is the bed side test for chorioamnionitis? ›

    MMP-8. The positive detection of MMP-8 (>20 ng/mL) in amniotic fluid on a rapid bedside test is associated with a significantly higher rate of intra-amniotic inflammation, proven amniotic fluid infection and histological chorioamnionitis as well as shorter interval to delivery and neonatal morbidity [86,87].

    What is the most common organism causing chorioamnionitis? ›

    The most common bacteria that cause chorioamnionitis are E. coli and group B strep.

    Can you see chorioamnionitis on ultrasound? ›

    Ultrasound assessment of fetal thymic perimeter and transverse diameter measurements have been demonstrated to predict FIRS and so chorioamnionitis in women with clinically diagnosed PPROM (evidence of pooled amniotic fluid on speculum with or without an adjunct bedside test).

    What is a chorio baby? ›

    Chorioamnionitis (chorio) is a bacterial infection of the mother's placenta and the amniotic fluid that surrounds the baby. It is diagnosed before or shortly after delivery. The bacteria that cause chorio are normally found in the mother's vagin*.

    What is funisitis? ›

    Funisitis is a mild inflammation of the umbilical stump with minimal drainage and erythema in the surrounding tissue.

    What is a Triple I infection in pregnancy? ›

    Triple I refers to intrauterine infection or inflammation or both and is defined by strict diagnostic criteria (table 1). These criteria are commonly used to diagnosis clinical chorioamnionitis even though the triple I terminology has not been adopted by most clinicians [2,3].

    How do you know if your amniotic fluid is infected? ›

    Chorioamnionitis is an infection of the placenta and the amniotic fluid. It happens more often when the amniotic sac is broken for a long time before birth. The major symptom is fever. Other symptoms include a fast heart rate, sore or painful uterus, and amniotic fluid that smells bad.

    How does a mom get chorioamnionitis? ›

    Most commonly, chorioamnionitis is associated with preterm labor, prolonged rupture of membranes, prolonged labor, tobacco use, nulliparous pregnancy, meconium-stained fluid, multiple vagin*l exams post rupture of membranes, and in women with known bacterial or viral infections.

    What is amniotic syndrome? ›

    What is amniotic band syndrome? Amniotic band syndrome is a rare condition that occurs when fibrous bands of the amniotic sac (the lining inside the uterus that holds the fetus) get tangled around parts of the developing fetus. Amniotic band syndrome affects about one in every 10,000 to 15,000 pregnancies.

    What happens if you are GBS positive in pregnancy? ›

    In pregnant women, GBS can cause infection of the urinary tract, placenta, womb, and amniotic fluid. Even if they haven't had any symptoms of infection, pregnant women can pass the infection to their babies during labor and delivery.

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